How is NuTec different from other clinical tests?
NuTEC is envisioned as a single device diagnosing many diseases as opposed to many individual tests in the hospital each diagnosing a single disease.
How do NuTec signatures work differently from individual tests?
The two are not mutually exclusive. Signatures allow you to ask the open-ended and unbiased question: ‘Is there a problem?’ However, if you have a specific question such as ‘Do I have diabetes mellitus?’ a specific test for glucose levels would make more sense.
Does NuTec detect DNA, RNA, proteins or small molecules?
NuTec is unbiased and reacts with all 4 classes. The resulting spots on the NuTec are not DNA, RNA, proteins and small molecules but rather the colorimetric products of these chemical reactions.
How is the NuTec signature generated?
A mixture of molecules in a sample applied to the NuTec undergoes chemical reactions upon heating which then result in a visual pattern of dark and light spots. By design, each spot on the NuTec reacts differently with the sample molecules. Physicochemical diversity among the spots is important for NuTec to search through a large enough chemical space in the sample. This diversity is the basis for generating the spot pattern.
What is the NuTec signature?
The NuTec signature is analogous to a hash function. A hash function takes information of arbitrary length (e.g. a large image file) and generates an output signature with a drastically smaller length (e.g. a string of 32 characters). The NuTec is the chemical version of a hash function. Just like a hash function, NuTec takes dimensionally large chemical information in a sample and reduces it to a chemical hash of X defined spots. Hash signatures are a great way of telling if a file downloaded off the internet matches the original. In the same way, Entopsis will be matching your chemical hash signature to a database of pre-validated hashes.
Are there other current approaches using signatures and how is NuTec different?
What sets NuTec apart from other platforms is the chemical hash concept. Chemical hashing does several things. It transforms chemical information into colorimetric information which can be acquired by a scanner or phone camera. It lets NuTec survey a chemical space which is unimaginably complex. The resulting hash signature is compact and easily amenable to database storage and template matching.
Is Entopsis ISO certified?
Yes, Dr. Tingjun Lei and the Entopsis manufacturing team have achieved ISO 9001:2015 and ISO 13485:2016 certification for the manufacture and sale of NuTec devices.
The Entopsis Family Grows with the Launch of the Global Health Institute
Have you ever read about cool, new medical products / tests, only to later realize it won’t be available for years into the future (if ever)?
Entopsis is effectively a R&D company that creates novel, impactful technologies for the bio-medical space. They are best known for OpsisDx™ (single platform to diagnose diseases early through urine) and PCRopsis™ (clinical tools that make diagnostic tests more efficient). This team of hard-core scientists and engineers usually rather license technologies, than sell directly to consumers.
This is where the Global Health Institute (GHI) comes in. GHI’s mission is to de-risk new clinical technologies by
Beyond COVID-19 Testing: Reagent RVD Facilitates Extraction-free Amplification of Bacteria
Reagent RVD has proven capable of amplifying SARS-CoV-2 gene targets directly from universal viral transport (UVT) medium without the need for viral RNA extraction. However, diagnostic reference laboratories also want to use this approach for the amplification of bacterial gene targets.
The PCRopsis™ research team has extended their validation efforts in this direction. It’s been confirmed that Reagent RVD is capable of mediating extraction-free qPCR of specimens containing gram positive and negative bacteria.
To date, Reagent RVD facilitates extraction-free amplification of viral, bacterial and human gene targets directly from UVT.
This opens the door to new applications with Reagent
Non-invasive OpsisDx Diagnostic Test Awarded US Academy of Medicine Research Global Award
The U.S. National Academy of Medicine’s Healthy Longevity Global Grand Challenge has awarded a grant to develop Entopsis’ OpsisDx(TM) platform for detecting Parkinson’s disease using skin swabs or urine. This effort is driven by Entopsis’ scientific and clinical collaborators at Singapore’s Temasek Life Sciences Laboratory (TLL) and National Neuroscience Institute (NNI).
Read more about it here:
Non-invasive OpsisDx Diagnostic Test Awarded US Academy Research Grant